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Forum >> HRT
HRT Posted by S M.
Wed Jan 30, 2008 05:24 pm
Hi Paul,
There is so much conflicting information about HRT. Where can I find up to date reading? For example a recent article in BMJ (BMJ 2007;335:219-220 (4 August), doi:10.1136/bmj.39272.445428.80 (published 11 July 2007) claimed that HRT can be cardioprotective in young women( ie less than 60) which is in conflict with the conventional thinking. what is your thinking on this?
Posted by PAUL A.
Wed Jan 30, 2008 09:39 pm
Below is the conclusion of the original research paper published in the same volume of the BMJ:

Conclusions Hormone replacement therapy increases cardiovascular and thromboembolic risk when started many years after the menopause. The results are consistent with the findings of the women\'s health initiative study and secondary prevention studies. Research is needed to assess the long term risks and benefits of starting hormone replacement therapy near the menopause, when the effect may be different.

You should read the paper rather than just the accompanying editorial.

Sub-group analysis of studies like the WHI trial suggest that HRT is not harmful (with respect to cardiovascular risk) in younger women. Whether it is protective is less clear, and the age at which it switches from being protective to being harmful will be difficult to determine. So the advice to women should remain unchanged - HRT is associated with an increased risk of cardiovascular disease ESPECIALLY in older women and those with a previous event and especially in the first year of use.