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MRCOG PART 2 SBAs and EMQs

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SBA 5

SBA 5 Posted by PAUL A.

Question 1

Gynaecological cancers can be hereditary. What proportion of these gynaecological cancers are hereditary?

 

a)     6-8% cervical cancers and 20% ovarian cancers

b)     4-5% endometrial cancers and 6-8% cervical cancers

c)     5-5% endometrial cancers and 20% ovarian cancers                      

d)     4-5% ovarian cancers and 5% endometrial cancers

e)     10% endometrial cancers and 30-40% ovarian cancers

 

Question 2

Some gynaecological cancers are hereditary. The predominant mode of inheritance is

 

a)     Autosomal dominant                                         

b)     Autosomal recessive

c)     X-linked recessive

d)     X-linked dominant

e)     Autosomal recessive with variable penetrance

 

Question 3

A 23 year old woman attends the gynaecology clinic following a diagnosis of breast cancer in her sister. After testing, she is found to be a carrier of the BRCA 1 mutation. Her risk of developing ovarian cancer by the age of 70 years is

a)     10%

b)     25%

c)     40%

d)     65%                          

e)     85%

 

Question 4

A 23 year old woman attends the gynaecology clinic following a diagnosis of breast cancer in her sister. After testing, she is found to be a carrier of the BRCA 2 mutation. Her risk of developing breast cancer by the age of 70 years is

 

a)     25%

b)     45%

c)     55%

d)     65%

e)     85%                                            

 

Question 5

With respect to gynaecological malignancies in women with the BRCA 1 or 2 mutation

 

a)     Ovarian cancers tend to be mucinous cystadenocarcinomas

b)     Breast cancers are typically slow-growing

c)     Ovarian cancers tend to be low-grade endometroid carcinomas

d)     Ovarian cancers tend to be high grade serous adenocarcinomas                               

e)     The lifetime risk of ovarian cancer is typically higher than the lifetime risk of breast cancer

 

Question 6

A23 year old woman has been referred to the gynaecology clinic because of concerns about her risk of developing gynaecological cancers. Her mother developed ovarian cancer 15 years ago at the age of 45 years and died 5 years ago.  Her 30 year old sister who lives abroad has also been diagnosed with breast cancer at the age of 35 years. Genetic testing has shown that her sister is a carrier of the BRCA 1 mutation.

 

a)     Refer for genetic counselling and BRCA 1 and 2 diagnostic testing                              

b)     Refer for genetic counselling and BRCA 1 and 2 predictive testing

c)     Offer BRCA 1 and 2 diagnostic testing once her family is complete

d)     Offer BRCA 1 and 2 predictive testing once her family is complete

e)     Reassure as over 50% of breast cancers have the BRCA 1 mutation

Posted by PAUL A.

Answers

 

1)   C

2)   A

3)   D

4)   E

5)   D

6)   A

Posted by Anuradha M.

would the answer of Q6 be B predictive testing? as she herself does not any malignancy?