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MRCOG PART 2 SBAs and EMQs

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EMQ1462
SBA2091
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Main ovarian androgen

Main ovarian androgen Posted by ghada S.

Dear Paul: the notes say that the main ovarian androgen is testosterone....

but  TOG July 2013 : the polycystic ovary syndrome & deffrential diagnosis of hyperandrogenism stated that the main ovarian androgen is androstendione....

Please clarify...

thank you 

Posted by PAUL A.

Have not read the article you describe but what you have written is biochemically inaccurate.

 

Testosterone and its biologically active metabolite dihydrotestosterone (DHT) are the only androgens with direct androgenic activity. DHEAS, DHEA, and androstenedione are all precursors of testosterone.