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MRCOG PART 2 SBAs and EMQs

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EMQ1476
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Tamoxifen

Tamoxifen Posted by ghada S.

Dear  Paule: 

As I understand from your own notes  that both clomiphene & tamoxifen are used to induce ovulation...

clomiphen compete with endogenous E at hypothalamus causes increase in gonadotrophin & serum estradiol.

Tamoxifen  increases serum estradiol while the level of gonadotrophin remain unchanged.

My Q is:     why gonadotrophin remain unchanged with tamoxifen & how it induce ovulation???

Please clarify...

Thank you...