Dear Paul could you please explain this Question: 5-alpha reductase deficiency
Is associated with an increased risk of malignancy in the gonads
True
False
Your answer: True
Correct answer: False
As I know that xy gonads are at high risk of malignancy & gonadectomy should be performed. Is 5 alpha reductase an exception of this?? Thank you very much.
Posted by Farrukh G.
Not sure what you mean by XY gonads. Individuals with 5-alpha reductase deficiency are genetically male (46XY) but may have female / indeterminate phenotype because of androgen deficiency. Increased risk of gonadoblastoma is because of undescended testes rather than 5-alpha reductase deficiency per se. If cryptorchidism is corrected then the risk of malignancy is not increased. We have made that clearer in the explanation.
