The smart way to learn. The smart way to teach.

MRCOG PART 2 SBAs and EMQs

Course PAID
notes336
EMQ1502
SBA2115
Do you realy want to delete this discussion?
Forum >>

5- alpha reductase

5- alpha reductase Posted by ghada S.

Dear Paul could you please explain this Question:                                                                                        5-alpha reductase deficiency

Is associated with an increased risk of malignancy in the gonads

  True

  False

Your answer: True

Correct answer: False

 

As I know that xy gonads are at high risk of malignancy & gonadectomy should be performed. Is 5 alpha reductase an exception of this??                                                                                                                      Thank you very much.

Posted by Farrukh G.

Not sure what you mean by XY gonads. Individuals with 5-alpha reductase deficiency are genetically male (46XY) but may have female / indeterminate phenotype because of androgen deficiency. Increased risk of gonadoblastoma is because of undescended testes rather than 5-alpha reductase deficiency per se. If cryptorchidism is corrected then the risk of malignancy is not increased. We have made that clearer in the explanation.