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MRCOG PART 2 SBAs and EMQs

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5- alpha reductase

5- alpha reductase Posted by ghada S.

Dear Paul could you please explain this Question:                                                                                        5-alpha reductase deficiency

Is associated with an increased risk of malignancy in the gonads

  True

  False

Your answer: True

Correct answer: False

 

As I know that xy gonads are at high risk of malignancy & gonadectomy should be performed. Is 5 alpha reductase an exception of this??                                                                                                                      Thank you very much.

Posted by Farrukh G.

Not sure what you mean by XY gonads. Individuals with 5-alpha reductase deficiency are genetically male (46XY) but may have female / indeterminate phenotype because of androgen deficiency. Increased risk of gonadoblastoma is because of undescended testes rather than 5-alpha reductase deficiency per se. If cryptorchidism is corrected then the risk of malignancy is not increased. We have made that clearer in the explanation.